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Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults123

Identifieur interne : 000482 ( Main/Exploration ); précédent : 000481; suivant : 000483

Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults123

Auteurs : Oana M. Deac ; James L. Mills [États-Unis] ; Barry Shane [États-Unis] ; Ivind Midttun [Norvège] ; Per M. Ueland [Norvège] ; John T. Brosnan [Canada] ; Margaret E. Brosnan [Canada] ; Eamon Laird [Irlande (pays)] ; Eileen R. Gibney [Irlande (pays)] ; Ruzong Fan [États-Unis] ; Yifan Wang [États-Unis] ; Lawrence C. Brody [États-Unis] ; Anne M. Molloy [Irlande (pays)]

Source :

RBID : PMC:4381767

Abstract

Background: Abnormalities of tryptophan (Trp) metabolism through the kynurenine (Kyn) pathway have been reported in various diseases; however, nutritional and lifestyle factors that affect this pathway in healthy individuals are not well documented.

Objective: Our aim was to examine the effect of vitamin B-6 status and lifestyle factors including the use of vitamin B-6 supplements, alcohol, smoking, and oral contraceptives on Trp and its Kyn metabolites in a cohort of 2436 healthy young adults aged 18–28 y.

Methods: Anthropometric and lifestyle data were collected by questionnaire. Participants provided blood samples for analysis of Trp, Kyn, anthranilic acid, kynurenic acid (KA), 3-hydroxykynurenine (HK), 3-hydroxyanthranilic acid (HAA), and xanthurenic acid (XA). Vitamin B-6 species were also measured.

Results: Serum Trp metabolites were 10–15% higher among men (n = 993) compared with women (n = 1443; P < 0.0001), except for HK and XA. In all participants, serum Trp was positively associated with plasma pyridoxal 5′-phosphate (PLP; r = 0.28, P < 0.0001), reaching a plateau at PLP concentrations of ∼83 nmol/L. HK was inversely associated with PLP (r = −0.14, P < 0.01). Users of vitamin B-6 supplements (n = 671) had 6% lower concentrations of HK than nonusers (n = 1765; P = 0.0006). Oral contraceptive users (n = 385) had lower concentrations of KA (20.7%) but higher XA (24.1%) and HAA (9.0%) than did nonusers (n = 1058; P < 0.0001). After adjustment for gender and other lifestyle variables, XA concentrations were 16% higher in heavy drinkers (n = 713) than in never or occasional drinkers (n = 975; P = 0.0007). Concentrations of 2 other essential amino acids, methionine and arginine, also were positively associated with serum Trp (r = 0.65 and 0.33, respectively; P < 0.0001).

Conclusions: In this population of healthy young adults, gender has the largest influence on serum Kyn metabolite concentrations. The significant covariance of Trp with unrelated amino acids suggests that protein intake may be an important consideration in evaluating Kyn metabolism.


Url:
DOI: 10.3945/jn.114.203091
PubMed: 25833774
PubMed Central: 4381767


Affiliations:

Links toward previous steps (curation, corpus...)

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National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff>
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<nlm:aff id="aff2">Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;</nlm:aff>
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<wicri:noRegion>Dublin</wicri:noRegion>
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<name sortKey="Gibney, Eileen R" sort="Gibney, Eileen R" uniqKey="Gibney E" first="Eileen R" last="Gibney">Eileen R. Gibney</name>
<affiliation wicri:level="1">
<nlm:aff wicri:cut="; and" id="aff8">Institute of Food and Health, University College Dublin, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Institute of Food and Health, University College Dublin, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
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<author>
<name sortKey="Fan, Ruzong" sort="Fan, Ruzong" uniqKey="Fan R" first="Ruzong" last="Fan">Ruzong Fan</name>
<affiliation wicri:level="2">
<nlm:aff id="aff3">Division of Intramural Population Health Research,
<italic>Eunice Kennedy Shriver</italic>
National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea> National Institute of Child Health and Human Development, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Wang, Yifan" sort="Wang, Yifan" uniqKey="Wang Y" first="Yifan" last="Wang">Yifan Wang</name>
<affiliation wicri:level="2">
<nlm:aff id="aff3">Division of Intramural Population Health Research,
<italic>Eunice Kennedy Shriver</italic>
National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea> National Institute of Child Health and Human Development, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
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<name sortKey="Brody, Lawrence C" sort="Brody, Lawrence C" uniqKey="Brody L" first="Lawrence C" last="Brody">Lawrence C. Brody</name>
<affiliation wicri:level="2">
<nlm:aff id="aff9">Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Molloy, Anne M" sort="Molloy, Anne M" uniqKey="Molloy A" first="Anne M" last="Molloy">Anne M. Molloy</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="aff1">Schools of Medicine</nlm:aff>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Biochemistry and Immunology, Trinity College Dublin, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
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<title level="j">The Journal of Nutrition</title>
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<idno type="eISSN">1541-6100</idno>
<imprint>
<date when="2015">2015</date>
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<div type="abstract" xml:lang="en">
<p>
<bold>Background:</bold>
Abnormalities of tryptophan (Trp) metabolism through the kynurenine (Kyn) pathway have been reported in various diseases; however, nutritional and lifestyle factors that affect this pathway in healthy individuals are not well documented. </p>
<p>
<bold>Objective:</bold>
Our aim was to examine the effect of vitamin B-6 status and lifestyle factors including the use of vitamin B-6 supplements, alcohol, smoking, and oral contraceptives on Trp and its Kyn metabolites in a cohort of 2436 healthy young adults aged 18–28 y. </p>
<p>
<bold>Methods:</bold>
Anthropometric and lifestyle data were collected by questionnaire. Participants provided blood samples for analysis of Trp, Kyn, anthranilic acid, kynurenic acid (KA), 3-hydroxykynurenine (HK), 3-hydroxyanthranilic acid (HAA), and xanthurenic acid (XA). Vitamin B-6 species were also measured. </p>
<p>
<bold>Results:</bold>
Serum Trp metabolites were 10–15% higher among men (
<italic>n</italic>
= 993) compared with women (
<italic>n</italic>
= 1443;
<italic>P</italic>
< 0.0001), except for HK and XA. In all participants, serum Trp was positively associated with plasma pyridoxal 5′-phosphate (PLP;
<italic>r</italic>
= 0.28,
<italic>P</italic>
< 0.0001), reaching a plateau at PLP concentrations of ∼83 nmol/L. HK was inversely associated with PLP (
<italic>r</italic>
= −0.14,
<italic>P</italic>
< 0.01). Users of vitamin B-6 supplements (
<italic>n</italic>
= 671) had 6% lower concentrations of HK than nonusers (
<italic>n</italic>
= 1765;
<italic>P</italic>
= 0.0006). Oral contraceptive users (
<italic>n</italic>
= 385) had lower concentrations of KA (20.7%) but higher XA (24.1%) and HAA (9.0%) than did nonusers (
<italic>n</italic>
= 1058;
<italic>P</italic>
< 0.0001). After adjustment for gender and other lifestyle variables, XA concentrations were 16% higher in heavy drinkers (
<italic>n</italic>
= 713) than in never or occasional drinkers (
<italic>n</italic>
= 975;
<italic>P</italic>
= 0.0007). Concentrations of 2 other essential amino acids, methionine and arginine, also were positively associated with serum Trp (
<italic>r</italic>
= 0.65 and 0.33, respectively;
<italic>P</italic>
< 0.0001). </p>
<p>
<bold>Conclusions:</bold>
In this population of healthy young adults, gender has the largest influence on serum Kyn metabolite concentrations. The significant covariance of Trp with unrelated amino acids suggests that protein intake may be an important consideration in evaluating Kyn metabolism.</p>
</div>
</front>
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<li>États-Unis</li>
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<li>Maryland</li>
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<name sortKey="Wang, Yifan" sort="Wang, Yifan" uniqKey="Wang Y" first="Yifan" last="Wang">Yifan Wang</name>
</country>
<country name="Norvège">
<noRegion>
<name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name>
</noRegion>
<name sortKey="Ueland, Per M" sort="Ueland, Per M" uniqKey="Ueland P" first="Per M" last="Ueland">Per M. Ueland</name>
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<country name="Canada">
<noRegion>
<name sortKey="Brosnan, John T" sort="Brosnan, John T" uniqKey="Brosnan J" first="John T" last="Brosnan">John T. Brosnan</name>
</noRegion>
<name sortKey="Brosnan, Margaret E" sort="Brosnan, Margaret E" uniqKey="Brosnan M" first="Margaret E" last="Brosnan">Margaret E. Brosnan</name>
</country>
<country name="Irlande (pays)">
<noRegion>
<name sortKey="Laird, Eamon" sort="Laird, Eamon" uniqKey="Laird E" first="Eamon" last="Laird">Eamon Laird</name>
</noRegion>
<name sortKey="Gibney, Eileen R" sort="Gibney, Eileen R" uniqKey="Gibney E" first="Eileen R" last="Gibney">Eileen R. Gibney</name>
<name sortKey="Molloy, Anne M" sort="Molloy, Anne M" uniqKey="Molloy A" first="Anne M" last="Molloy">Anne M. Molloy</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000482 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000482 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4381767
   |texte=   Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults123
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25833774" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1
Wicri

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022